The MSOT devices from iThera for preclinical and clinical research. The imaging method used by iThera is based on the photoacoustic effect. In simple terms, a laser with nanosecond pulses is directed at the tissue to be examined. Where the light is absorbed by the tissue, thermoelastic expansion takes place, resulting in a spherical ultrasound wave that propagates through the tissue to the detector. Or in short: "Light in, ultrasound out"." From this, the device reconstructs an image with optical contrast, which allows various disease processes to be detected and diagnoses to be made. iThera calls this method multispectral optoacoustic tomography (MSOT).